Jared Carl Ehrhart;Svitlana Garbuzova-Davis;Paul R. Sanberg
发明人:
Svitlana Garbuzova-Davis,Jared Carl Ehrhart,Paul R. Sanberg
申请号：
US16655506
公开号：
US20200061123A1
申请日:
2019.10.17
申请国别(地区):
US
年份:
2020
代理人:
摘要：
A method of treating neurodegenerative diseases using hUCB plasma is presented herein. hUCB plasma attenuated the hyperactive response (Group III) and potentiated the normal response in Group I ALS patients, but did not alter that of the non-responders to PHA (Group II). The elevated activity of caspase 3/7 observed in the MNCs from ALS patients was significantly reduced by hUCB plasma treatment. The ability of hUCB plasma to modulate the mitogen cell response and reduce caspase activity suggest that the use of hUCB plasma alone, or with stem cells, may prove useful as a therapeutic in ALS patients. hUCB plasma was shown to increase therapeutic efficacy of MNCs as well as decrease apoptosis of MNCs. The cytokine profile of hUCB plasma supports its usefulness as a sole therapeutic as well as an additive to MNCs.
