The present invention is excellent in the storage stability of the antioxidant and a long period of time, and also the practical strength to have, besides the production rationality high polysulfone-based blood treatment membrane and also the risk of endotoxin intrusion of the high at the same time, the storage stability of the antioxidant and long-term treatment solution this low, and it has a practical strength, yet providing a high production rationality the polysulfone-based blood treatment membrane, and a method of manufacturing the same.Polysulfone-based resin, a hydrophilic polymer and a hydrophobic antioxidant comprising the blood treatment membrane, is a per 1 g fat soluble antioxidant film 30 mg ~ 76 mg-containing, and the total of the fat-soluble antioxidant film on the surface film 1 per g 4 mg ~ polysulfone-based blood treatment membrane, and, 1.8 × in 1 g per fat-soluble antioxidants to 30 mg ~ 76 mg-containing and, TOF-SIMS of the fat-soluble antioxidant normalized peak intensity of the film the inner surface characterized in that the 25 mg 10 -4 or more, the outer membrane as a polysulfone-based blood treatment membrane, and, polysulfone-based resin and a hydrophilic polymer and a lipid-soluble antioxidants consisting of the blood treatment membrane method characterized in that 2.4 × 10 -4 or more in the surface, per 1 g after the fat-soluble antioxidants to obtain a membrane intermediate that contains 30 mg ~ 76 mg, 100 ℃ the film intermediate to dryness ~ 180 ℃, polysulfone-based blood treatment membrane characterized in that the heat treatment is 0.1 bun ~ 360 bungan .본 발명은, 항산화성과 장기간의 보존 안정성이 우수하고, 또한 실용 강도를 가지며, 게다가 생산 합리성이 높은 폴리술폰계 혈액 처리막, 또한 항산화성과 장기간의 보존 안정성이 우수한 동시에 처리액에의 엔도톡신 침입의 위험성이 적고, 또한 실용 강도를 가지며, 게다가 생산 합리성이 높은 폴리술폰계 혈액 처리막, 및 그 제조 방법을 제공한다.폴리술폰계 수지, 친수성 고분자 및 지용성 항산화제로 이루어지는 혈액 처리막으로서, 이 막은 1 g당 지용성 항산화제를 30 mg~76 mg 함유하고, 막 표면에 존재하는 지용성 항산화제의 총합이 막 1 g당 4 mg~25 mg인 것을 특징으로 하는 폴리술폰계 혈액 처리막, 또한, 1 g당 지용성 항산화제를 30 mg~76 mg 함유하고, 지용성 항
