HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF

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专利权人:

发明人:

申请号：

HK12101964.6

公开号：

HK1161250A

申请日:

2012.02.27

申请国别(地区):

HK

年份:

2012

代理人:

摘要：

Disclosed are MEK inhibitors having the Formula I or a pharmaceutically acceptable salt thereof, wherein: R 1 is Cl or F R 3 is H, Me, Et, OH, MeO-, EtO-, HOCH 2 CH 2 O-, HOCH 2 C(Me) 2 O-, (S)-MeCH(OH)CH 2 O-, (R)-HOCH 2 CH(OH)CH 2 O-, cyclopropyl-CH 2 O-, HOCH 2 CH 2 -, R 7 is cyclopropyl-CH 2 - or C 1 -C 4 alkyl, wherein said alkyl is optionally substituted with one or more F R 8 is Br, I or SMe and R 9 is CH 3 , CH 2 F, CHF 2 , CF 3 , F or Cl, useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions.

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