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Pyrrolone melanin concentrating hormone receptor-1 antagonists
专利权人:
Guohua Zhao
发明人:
Guohua Zhao,William N. Washburn,James J. Mignone
申请号:
US13122833
公开号:
US08344160B2
申请日:
2009.10.08
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula Iwherein R1,R4, R5,R3, R3a, W, D, R2a, R2b and R2c are defined herein.Additionally, the present application provides pharmaceutical compositions containing at least one compound according to Formula I and optionally at least one additional therapeutic agent. Finally, the present application provides methods for treating a patient suffering from an MCHR-1 modulated disease or disorder such as, for example, obesity, diabetes, depression, anxiety or intestinal inflammation, by administration of a therapeutically effective dose of a compound according to Formula I.
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