NICOLAU, CLAUDE YVES,GREFERATH, RUTH,HICKMAN, DAVID
申请号：
AT05723323
公开号：
AT552848T
申请日:
2005.02.22
申请国别(地区):
AT
年份:
2012
代理人:
摘要：
The present invention comprises novel compositions and methods for eliciting high immune responses, of great specificity yielding conformationally sensitive antibodies. These antibodies recognize specific epitopes on a wide variety of antigens including but not limited to, amyloid protein, prion protein, P 170 glycoprotein. The novel compositions of the invention comprise surpamolecular antigenic constructs generally comprising a peptide sequence, covalently attached to pegylated lysine resulting in modified and enhanced peptide presentation. The unique modification methodology of the present invention is applicable to a variety of peptides and can ultimately be employed in therapeutic formulations and vaccines for diseases and disorders such as Alzheimer's disease.
