JONES, ROBERT M.,LEHMANN, JUERG,CHEN, WEICHAO,EDWARDS, JEFFREY,MARQUEZ, GLEN,MORGAN, MICHAEL E.,SADEQUE, ABU J. M.,KIM, SUN HEE
申请号：
PE0006242013
公开号：
PE13712013A1
申请日:
2011.09.21
申请国别(地区):
PE
年份:
2013
代理人:
摘要：
Refers to compounds GPR119 receptor agonists such as 3-fluoro-4 - (4-fluoro-6 - 5 - (4 - (3 - (2 - fluoropropan - 2 - il) - 1,2,4 - Oxadiazoles - 5 - il) piperidin-1-yl) - 4 - ilamino pyrimidin-2-yl) - n, N - dimetilbenzamida 3 - 4 - 5 - fluoro - (4-fluoro-6 - (4 - (3 - (2 - fluoropropan - 2 - il) - 1,2,4 - Oxadiazoles - 5 - il) piperidin-1-yl) - 4 - ilami pyrimidine Not) - n-methylbenzamide and 3 - 4 - 5 - fluoro - (4-fluoro-6 - (4 - (3 - (2 - fluoropropan - 2 - 1.2, - il)Oxadiazoles - 4 - 5 - il) piperidin-1-yl) - 4 - ilamino pyrimidin-2-yl) benzamide. It also relates to a Pharmaceutical composition comprising Said compound and a Second Pharmaceutical Agent such as a dpp-iv Inhibitor, a Biguanide, an inhibitor of alpha Glucosidase, a sulfonylurea, a meglitinide, among others.These compounds increase secretion of an incretin being useful in the treatment of Osteoporosis, rheumatoid arthritis, Type 2 diabetes, hyperlipidemiaSE REFIERE A COMPUESTOS AGONISTAS DEL RECEPTOR GPR119 TALES COMO 3-FLUORO-4-(5-FLUORO-6-(4-(3-(2-FLUOROPROPAN-2-IL)-1,2,4-OXADIAZOL-5-IL)PIPERIDIN-1-IL)PIRIMIDIN-4-ILAMINO)-N,N-DIMETILBENZAMIDA 3-FLUORO-4-(5-FLUORO-6-(4-(3-(2-FLUOROPROPAN-2-IL)-1,2,4-OXADIAZOL-5-IL)PIPERIDIN-1-IL)PIRIMIDIN-4-ILAMINO)-N-METILBENZAMIDA Y 3-FLUORO-4-(5-FLUORO-6-(4-(3-(2-FLUOROPROPAN-2-IL)-1,2,4-OXADIAZOL-5-IL)PIPERIDIN-1-IL)PIRIMIDIN-4-ILAMINO)BENZAMIDA. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA DE DICHO COMPUESTO Y UN SEGUNDO AGENTE FARMACEUTICO TAL COMO UN INHIBIDOR DE DPP-IV, UNA BIGUANIDA, UN INHIBIDOR DE ALFA-GLUCOSIDASA, UNA SULFONILUREA, UNA MEGLITINIDA, ENTRE OTROS. DICHOS COMPUESTOS INCREMENTAN LA SECRECION DE UNA INCRETINA SIENDO UTILES EN EL TRATAMIENTO DE OSTEOPOROSIS, ARTRITIS REUMATOIDE, DIABETES DE TIPO 2, HIPERLIPIDEMIA
