Nitric oxide-releasing polyaminoglycosides as biodegradable antibacterial scaffolds and methods pertaining thereto

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专利权人:

The University of North Carolina at Chapel Hill

发明人:

Schoenfisch, Mark H.,Yang, Lei

申请号：

AU2018247167

公开号：

AU2018247167A1

申请日:

2018.03.28

申请国别(地区):

AU

年份:

2019

代理人:

摘要：

Provided herein are hyperbranched polyaminoglycosides, where in some embodiments, the hyperbranched polyaminoglycosides are covalently modified to store and release nitric oxide. Some embodiments pertain to methods of making and use of hyperbranched polyaminoglycosides. In some embodiments, the covalently modified hyperbranched polyaminoglycosides may be tailored to release nitric oxide in a controlled manner and are useful for eradication of both gram positive and gram negative bacteria as well as other microbes.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/