This invention discloses that a combination of ceftriaxone and erythropoietin can be used in the treatment and/or prevention of Parkinson’s disease dementia (PDD).本發明揭示一包含有頭孢曲松(ceftriaxone)與紅血球生成素(erythropoietin)的組合可被用來治療和/或預防巴金森氏症失智(Parkinson’s disease dementia,PDD)。