SANTOSH K VERMA INDIA,PRASHANT MANI INDIA,NISHI RAJ SHARMA INDIA,ANUJA KRISHNAN INDIA,VALLURIPALLI VINOD KUMAR INDIA,BATHULA SURENDAR REDDY INDIA,ARABINDA CHAUDHURI INDIA,RAJENDRA P ROY INDIA,DEBO P S
申请号：
IN1003/DEL/2005
公开号：
IN300602B
申请日:
2005.04.21
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
A process for producing a targeted gene and/or drug delivery system for liver cells comprising the steps of: i. chemical reduction of Sendai virus for reduction of HN protein ii. subjecting the reduced virus to the step of dialysis for removal of the reducing agent iii. solubilizing the reduced virus with a detergent to obtain a solution iv. centrifuging the solution to separate the insolubles consisting of reduced HN protein and core of said virus v. adding histidylated lipid to the supernatant vi. adding the drug or gene after addition of the lipid vii. removing the detergent from the envelope and then subjecting it to the step of centrifugation to obtain His lipid F-virosomes with entrapped drug or DNA. WO2006111982A1
