Orthodontic appliance systems including self-ligating orthodontic brackets and/or orthodontic brackets that include a prescription-altering insert that is configured to be removably coupled to the bracket. The prescriptive insert may be optional in some embodiments. In some embodiments, the prescriptive insert may define and/or alter the prescription of the bracket, such as a prescription defined by the bracket when the insert is not utilized. A plurality of prescriptive inserts may be provided, with each insert defining a unique orthodontic prescription when coupled to the bracket. In some embodiments, the bracket is a self-ligating bracket that includes a base and a repositionable closure for selectively obstructing an opening in an archwire passage of the bracket. In some embodiments, the closure defines more than one side, or wall, of the archwire passage and/or is pivotally coupled to the base by a floating hinge or other displaceable positioning mechanism.
