An object of the present invention is to provide an orally disintegrating tablet and the like having excellent tablet hardness and disintegration even when the content of medicinal ingredients is high. The present invention relates to an orally disintegrating tablet comprising a disintegrating particle composition produced by at least a two-stage granulation method and a medicinal ingredient having a distribution coefficient of −6.0 to 10.0, in particular, tablet hardness is The present invention relates to the orally disintegrating tablet having a disintegration time in water of 30 to 100 N and 10 to 30 seconds.本発明の目的は、薬効成分の含量が高くとも、優れた錠剤硬度と崩壊性を有する口腔内崩壊錠剤等を提供することである。本発明は、少なくとも二段階の造粒法で製造された崩壊性粒子組成物、及び、分配係数が－６．０～１０．０である薬効成分を含む口腔内崩壊錠剤、特に、錠剤硬度が３０～１００Nであり、水中崩壊時間が１０～３０秒であるような該口腔内崩壊錠剤等に関する。
