flu hemagglutinin stem domain polypeptide, nucleic acid molecule, vector, and, composition

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专利权人:

CRUCELL HOLLAND B.V.

发明人:

Antonietta Impagliazzo,Jan Wilem Meijberg,Jehangir Wadia,Katarina Radosevic,Michelle Wagner,Robert Anthony Williamson,Zhaoqing Ding

申请号：

BR112015029635

公开号：

BR112015029635A2

申请日:

2014.05.27

申请国别(地区):

BR

年份:

2017

代理人:

摘要：

1/1 summary "influenza hemagglutinin stem domain polypeptide, nucleic acid molecule, vector, and, composition" The present invention provides polypeptides of the influenza hemagglutinin stem domain. influenza hemagglutinin stem comprising (a) an influenza haemagglutinin domain ha1 comprising a ha1 n-terminal stem segment comprising amino acids from position 1 to position ox, preferably from the op position to the ox position of the ha1 domain, covalently linked by a linkage sequence of 0-50 amino acid residues to a c-terminal stem segment of ha1, comprising amino acids from the y position to and including the c-terminal amino acid of the ha1 domain and (b) an influenza haemagglutinin domain ha2, wherein the hemagglutinin stem domain polypeptide is resistant to protease cleavage at the junction between ha1 and ha2, and wherein one or more amino acids of the amino acids at positions 337, 340, 352, 353, 402, 406, 409, 413 and / or 416 have been mutated compared to the corresponding positions in ha of wild-type influenza.1 / 1 resumo “polipeptã�deo do domã�nio de haste da hemaglutinina da gripe, molã‰cula de ã�cido nucleico, vetor, e, composiã‡ãƒoâ€� a presente invenã§ã£o proporciona polipeptã­deos do domã­nio de haste da hemaglutinina da gripe compreendendo (a) um domã­nio ha1 da hemaglutinina da gripe que compreende um segmento de haste n-terminal de ha1, compreendendo os aminoã¡cidos desde a posiã§ã£o 1 atã© ã  posiã§ã£o x, preferencialmente desde a posiã§ã£o p atã© ã  posiã§ã£o x, do domã­nio ha1, covalentemente ligado por uma sequãªncia de ligaã§ã£o de 0-50 resã­duos de aminoã¡cidos a um segmento de haste c-terminal de ha1, compreendendo os aminoã¡cidos desde a posiã§ã£o y atã© e incluindo o aminoã¡cido c-terminal do domã­nio ha1 e (b) um domã­nio ha2 da hemaglutinina da gripe, em que o polipeptã­deo do domã­nio de haste da hemaglutinina ã© resistente a clivagem por proteases na junã§ã£o entre ha1 e ha2, e em que um ou mais amino dos aminoã¡cidos nas posiã§ãµes 3

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