METHODS AND MEANS OF GENERATING IL-17 ASSOCIATED ANTITUMOR EFFECTOR CELLS BY INHIBITION OF NR2F6 INHIBITION

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专利权人:

发明人:

David KOOS,Thomas ICHIM,Santosh KESARI

申请号：

US15431681

公开号：

US20170362596A1

申请日:

2017.02.13

申请国别(地区):

US

年份:

2017

代理人:

摘要：

Disclosed are means, methods, and compositions of matter useful for generation of cancer inhibitory effector cells producing interleukin-17 (IL-17). In one embodiment a cellular population is obtained, said cellular population is exposed to agents capable of inhibiting NR2F6, whereby said inhibition of NR2F6 results in upregulation of IL-17 production, said upregulation of IL-17 production associated with acquisition of anti-tumor activity.

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