An apparatus and method are provided for transmitting and receiving a quasi-cyclic Low Density Parity Check (LDPC) code in a multimedia communication system. In the method, a signal transmission apparatus generates a quasi-cyclic LDPC code, and transmits the quasi-cyclic LDPC code to a signal reception apparatus. The quasi-cyclic LDPC code is generated by encoding an information word vector using a child parity check matrix, generated by performing one of a scaling operation, a row separation operation, and a row merge operation on a parent parity check matrix. In the scaling operation, a size of the child parity check matrix is determined. In the row separation operation, each of rows included in the parent parity check matrix is separated. In the row merge operation, the rows included in the parent parity check matrix are merged.