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Peptides that Selectively Home to Heart Vasculature and Related Conjugates and Methods
专利权人:
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
发明人:
Lianglin Zhang,Jason Hoffman,Erkki Ruoslahti
申请号:
US14664910
公开号:
US20160022831A1
申请日:
2015.03.22
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The present invention provides a variety of isolated peptides and peptidomimetics, which can be useful, for example, in constructing the conjugates of the invention or, where the peptide itself has biological activity, in unconjugated form as a therapeutic for treating any of a variety of cardiovascular diseases as described below. Thus, the present invention provides an isolated peptide or peptidomimetic which has a length of less than 60 residues and includes the amino acid sequence CRPPR (SEQ ID NO: 1) or a peptidomimetic thereof. The invention further provides an isolated peptide or peptidomimetic which has a length of less than 60 residues and includes the amino acid sequence CARPAR (SEQ ID NO: 5) or a peptidomimetic thereof, or amino acid sequence CPKRPR (SEQ ID NO: 6) or a peptidomimetic thereof.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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