#$%^&*AU2018222971A120180920.pdf#####ABSTRACT Therapeutic compositions and/or formulations are provided, comprising: at least one crosslinked protein matrix, wherein the, at least one cross-linked protein matrix comprises at least one protein residue and at least one saccharide-containing residue, and methods of producing the 5 same. The cross-linked protein matrix may be derived from cross-linking a full length or substantially full length protein, such as tropoelastin, elastin, albumin, collagen, collagen monomers, immunoglobulins, insulin, and/or derivatives or combinations thereof, with a saccharide containing cross-linking agent, such as a polysaccharide cross-linking agent derived from, for example, hyaluronic acid or a cellulose derivative. The therapeutic compositions may 0 be administered topically or by injection. The present disclosure also provides methods, systems, and/or kits for the preparation and/or formulation of the compositions disclosed herein.
