Nicholas Phillip Mulholland,Edouard Godineau,Jérôme Yves Cassayre,Peter Renold,Myriem El Qacemi,Guillaume Revol
申请号：
US13581137
公开号：
US20140206633A1
申请日:
2011.02.03
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to processes for the preparation of compounds of formula IB wherein A1, A2, A3, A4, L, Y1, Y2, R1, R2, R3, R4 and R5 are as defined in the claims, comprising reacting a compound of formula (II) wherein Y1, Y2, L, A1, A2, R1, R2, R3, R4 and R5 are as defined for the compound of formula (I) with hydroxylamine in the presence of water, a base and a chiral phase transfer catalyst, which chiral phase transfer catalyst is a quinine derivative. The invention also relates to compounds of formula IB and enantiomerically enriched mixtures comprising compounds of formula IB.
