Lloyd F. Mackenzie,Thomas B. Macrury,Curtis Harwig,David Bogucki,Jeffery R. Raymond,Jeremy D. Pettigrew,Vladimir Khlebnikov,Rudong Shan
申请号：
US15370973
公开号：
US09937167B2
申请日:
2016.12.06
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Compounds of formula (I):wheren, R1, R4a, R4b, R5, R7 and R8 are defined herein, or pharmaceutically acceptable salts thereof, are described herein. The disclosed compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.
