The present invention provides compounds of Formula (I):wherein all of the variables are as defined herein. These compounds are modulators of NLRP3, which may be used as medicaments for the treatment of proliferative disorders, such as cancer in a subject (e.g., a human).本發明提供式(I)化合物:其中所有變數如本文中所定義。此等化合物為NLRP3調節劑,其可用作供治療個體(例如人類)之增生性病症(諸如癌症)之藥劑。