The present invention provides a patch preparationcontaining a support and an adhesive layer on at least onesurface of the support, wherein the adhesive layer contains adrug, amine oxide, a low-polar liquid component based on anorganic compound having an angle of 0 - 19° as calculated by theformula (I):angle (°)=arctan (inorganic value/organic value) x (180/.pi.) andusing an inorganic value and an organic value on an organicconceptual diagram, and an adhesive base, and the adhesivelayer has an amine oxide content of 0.1 - 5 wt% and a low-polarliquid component content of 30 - 50 wt%.
