Compounds and Compositions That Bind and Stabilize Transthyretin and Their Use for Inhibiting Transthyretin Amyloidosis and Protein-Protein Interactions
The Board of Trustees of the Leland Stanford Junior University
发明人:
Isabella A. Graef,Mamoun M. Alhamadsheh
申请号：
US15480139
公开号：
US20170340608A1
申请日:
2017.04.05
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Disclosed herein are compounds and compositions thereof which find use in increasing stability of proteins particularly proteins that tend to misfold and form aggregates. Also provided herein are methods for using these compounds and compositions for increasing stability of proteins and thereby decreasing aggregate formation by these proteins. Also disclosed herein are heterobifunctional compounds that include a TTR binding compound connected to a targeting moiety via a linker, for use in disrupting PPIs of a target protein.
