Methods, apparatus and systems for modifying apocrine glands are disclosed herein. A method for modifying apocrine glands may comprise inserting a tissue dissecting and modifying wand (TDM) into an incision in a patients skin. The TDM may comprise a tip having a plurality of protrusions with lysing segments positioned between the protrusions. The TDM may also comprise an energy window positioned on top of the TDM that is configured to deliver energy to incapacitate apocrine glands. After separating tissue using the lysing segment(s) to define a target region, the energy window may be activated and moved around within the target region to incapacitate apocrine glands. In some implementations, the energy window may be activated prior to separating the tissue such that the tissue is separated while apocrine glands are incapacitated within the target region.