The present invention provides polypeptides and polynucleotides encoding G protein coupled receptors, including GPR88, GPR22, and the Super conserved Receptors Expressed in Brain (SREB) G protein coupled receptors that are associated with neurological and metabolic diseases and disorders. The invention also provides methods for identifying modulators of G protein coupled receptor biological activity or expression, and for treating or preventing neurological and metabolic diseases and disorders using these G protein coupled receptor polypeptides, polynucleotides, and modulators, alone or in combination. The invention also provides diagnostic assays for detecting diseases or disorders associated with inappropriate G protein coupled receptor activity or expression, as well as animal models of neurological and metabolic diseases.
