DOMAINES DE LIAISON A L'ANTIGENE ANTI TRBC1

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专利权人:

AUTOLUS LIMITED

发明人:

CORDOBA, SHAUN,THOMAS, SIMON,ONUOHA, SHIMOBI,JHA, RAM,LIM, WEN CHEAN

申请号：

CA3065006

公开号：

CA3065006A1

申请日:

2018.06.08

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

The present disclosure relates to anti-TRBC1 antigen binding domainscharacterized by the sequences of the variablechains. The CDRs sequences of the variable chains are : (VH CDR1) GYTFT, (VHCDR2) NPYNDDIQS, (VH CDR3)GAGYNFDGAYRFFDF； and (VL CDR1) RSSQRLVHSNGNTYL, (VL CDR2) RVSNRFP, (VL CDR3)SQSTHVPYT. The claimedhumanized antibodies derive from the murine JOVI antibody. Uses in cancertherapy.

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