INDUSTRY-ACADEMIC COOPERATION FOUNDATION; YONSEI UNIVERSITY
发明人:
JANG, JAE HYUNG,장재형,LEE, SLGIRIM,이슬기림,CHU, HUN SU,추헌수,WON, JONG IN,원종인
申请号：
KR1020110109542
公开号：
KR1020130045086A
申请日:
2011.10.25
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A nanofiber electro spinning scaffold is provided to control output rate of the virus vector and control the speed of gene delivery by controlling the content, temperature and the likes.CONSTITUTION: A nanofiber electro spinning scaffold which controls the output rate of adeno-associated virus vectors is manufactured by dispersing adeno-associated virus, AAV vectors on elastin-like polypeptide having amino acid sequence which is expressed by structure formula 1 and nanofiber electro spinning of &epsi-carprolactone. In the formula &lsqbVPGXG&rsqbn, X indicates amino acid except proline and n indicates 32-128. X is valine and n is 128. The number of the average molecular weight of the poly (&epsi -carprolactone) is 80,000.COPYRIGHT KIPO 2013[Reference numerals] (AA,BB) Stir through the night (CC) PCL chain (DD) ELP chain본 발명은 아데노부속바이러스 벡터의 방출 속도를 제어하는 나노섬유 전기방사 스캐폴드에 관한 것으로, 엘라스틴 유사 폴리펩타이드와 폴리(ε-카프로락톤)의 나노섬유 전기방사체 상에 아데노부속바이러스 벡터를 분산시켜 바이러스 벡터의 방출 속도를 제어하여 유전자 전달 속도를 조절할 수 있다.
