Jun-Jen LIU,Yun-Long Tseng,Sheue-Fang SHIH,Luke S.S. GUO,Keelung HONG
申请号：
US14248633
公开号：
US20140287025A1
申请日:
2014.04.09
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention provides a sustained release composition for intravitreal injection to the eye of a subject in need thereof. The sustained release composition contains an effective amount of a therapeutic agent in association with a nanosphere. The nanosphere contains a particle that comprises a particle-forming component capable of forming a vesicle, and an agent-carrying component capable of forming a complex with the therapeutic agent via electrostatic charge-charge interaction or hydrophobic-hydrophobic interaction. The particle-forming component has at least one head group moiety selected from a hydrophobic head group moiety, a polar head group moiety and a combination thereof. The agent-carrying component is a chemical entity that contains one or more negatively or positively charged groups.
