Aleksandar Filip Radovic-Moreno,Weiwei Gao,Archana Swami,Gershon Golomb,Robert S. Langer,Omid C. Farokhzad
申请号：
US12762348
公开号：
US09532956B2
申请日:
2010.04.18
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention generally relates to polymers and particles, such as nanoparticles. The particles and polymers generally include one or more buffering components. Additionally, the particles and polymers may include two or more components that impart useful properties (functionalities). The particles and polymers, for example, may include a buffering component and a degradable component. As described herein, the particles and polymers may also include a hydrophilic component and/or a cleavable bond component. The particles and polymers described herein have been found to be particularly effective when used for delivery of one or more agents, such as one or more pharmaceutical agents. Other aspects of the invention are directed to methods of using or administering such particles or polymers, kits involving such particles or polymers, and the like. The present invention also relates to particles containing a cleavable bond component and one or more fluorescence resonance energy transfer (FRET) pairs as well as methods of detecting the cleavage of the cleavable bond component of such particles.
