The invention relates to a novel linker for use in bioconjugates such as antibody-drug-conjugates. The linker according to the invention is represented by formula: (I) wherein: - BM is a branching moiety - E is a capping group - SG is a sulfamide group - b, c, d, e, g, i, k, I are independently 0 or 1 - f is an integer in the range of 1 to 10 - Sp1, Sp2, Sp3, Sp4, Sp5 and Sp6 are a spacer moieties - Z1 and Z2 are connecting groups. The linker according to the invention is useful in the preparation of linker-conjugates and bioconjugates, and can be used for (a) improving conjugation efficiency in the preparation of the bioconjugate, (b) reducing aggregation during the preparation of the bioconjugate and/or of the bioconjugate, (c) increasing stability of the bioconjugate, and/or (d) increasing therapeutic index of the bioconjugate.
