Novel compositions of matter comprising a foamable delivery system areprovided. Novel methods for treating a disease, disorder, or condition usingthe novel compositions, are further provided. Novel methods for making anddelivering a foamable pharmaceutical composition are also provided. While thenovel compositions and foamable drug delivery system may be utilized foradministration of a wide variety of drugs to epithelialtissues, to treat awide variety of diseases, disorders, or conditions, the inventive compositionsand foamable drug delivery systems are particularly useful for thedermatological administration of corticosteroids and antifungal agents.