Mutated anthrax toxin protective antigen proteins that specifically target cells containing high amounts of cell-surface metalloproteinases or plasminogen activator receptors
Stephen H. Leppla,Shi-Hui Liu,Sarah Netzel-Arnett,Henning Birkedal-Hansen,Thomas Bugge
申请号：
US14313575
公开号：
US09403872B2
申请日:
2014.06.24
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention provides methods of specifically targeting compounds to cells overexpressing matrix metalloproteinases, plasminogen activators, or plasminogen activator receptors, by administering a compound and a mutant protective antigen protein comprising a matrix metalloproteinase or a plasminogen activator-recognized cleavage site in place of the native protective antigen furin-recognized cleavage site, wherein the mutant protective antigen is cleaved by a matrix metalloproteinase or a plasminogen activator overexpressed by the cell, thereby translocating into the cell a compound comprising a lethal factor polypeptide comprising a protective antigen binding site.
