FIVE PRIME THERAPEUTICS, INC.;BRISTOL-MYERS SQUIBB COMPANY;BRISTOL MYERS SQUIBB COMPANY
发明人:
JOHNSTON, ROBERT J.,RAJPAL, ARVIND,SHEPPARD, PAUL O.,BORGES, LUIS,RANKIN, ANDREW,BAHJAT, KEITH SADOON,KORMAN, ALAN J.,DENG, XIAODI,SU, LIN HUI,RAKESTRAW, GINGER,PINCKNEY, JASON R.,CRITTON, DAVID A.,CH
申请号：
CA3092589
公开号：
CA3092589A1
申请日:
2019.03.19
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significantly bind to human VISTA at neutral or physiological pH.
