STABLE FORMULATION DEVELOPMENT FOR NITROGLYCERIN SUBLINGUAL TABLETS BY DIRECT COMPRESSION TECHNIQUE WITH POVIDONE AND CROSPOVIDONE

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专利权人:

发明人:

SANGEETHA DHANARAJ,MANOJ KUMAR VADLAMUDI

申请号：

IN201641022805

公开号：

IN201641022805A

申请日:

2016.07.02

申请国别(地区):

IN

年份:

2018

代理人:

摘要：

A stable sublingual composition with fast disintegration time of less than 25 seconds is provided. The composition which is formulated into stable sublingual tablets by direct compression technique includes (a) 15% by wt. of 10% nitroglycerin in lactose (b) 76.0-78.3% by wt. of lactose monohydrate (c) 1.5-2.5% by wt. of povidone (d) 3.0-4.0% by wt. of crospovidone (e) 1.5-2.5% by wt. of colloidal silicon dioxide and (f) 0.5-1.0% by wt. of magnesium stearate.

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