This invention provides a system for operating RFID tags on a single-use connector. The system includes: a first single-use connector configured to receive a first RFID tag and a second single-use connector configured to receive a second RFID tag. The invention also includes a reader placed close to the first RFID tag and the second RFID tag. The reader is configured to: determine if the first RFID tag and the second RFID tag are gamma sterilized determine if the first RFID tag and the second RFID tag were previously used determine if the first RFID tag and the second RFID tag are authentic and determine if the first RFID tag matches with the second RFID tag.
