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Stabilized anti-RSV antibody liquid formulation
专利权人:
メディミューン,エルエルシー;メディミューン,エルエルシー
发明人:
オリヴァー,シンシア,エヌ.,シェーン,エリカ,アイザックス,ベンジャミン,エス.,アラン,クリスチャン,ビー.,チャン,スティーブン,オリヴァー,シンシア,エヌ.,シェーン,エリカ,アイザックス,ベンジャミン,エス.,アラン,クリスチャン,ビー.,チャン,スティーブン
申请号:
JP2010165408
公开号:
JP5443291B2
申请日:
2010.07.23
申请国别(地区):
JP
年份:
2014
代理人:
摘要:
The present invention provides liquid formulations of SYNAGIS ® or an antigen binding fragment thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which formulations exhibit stability, low to undetectable levels of aggregation, and very little to no loss of the biological activities of SYNAGIS ® or an antigen-binding fragment thereof, even during long periods of storage. In particular, the present invention provides liquid formulations of SYNAGIS ® or an antigen-binding fragment thereof which immunospecifically binds to a RSV antigen, which formulations are substantially free of surfactant, inorganic salts, and/or other common excipients. Furthermore, the invention provides methods of preventing, treating or ameliorating symptoms associated with RSV infection utilizing liquid formulations of the present invention.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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