The present invention relates to a process for decontaminating by irradiation the interior of a thermoplastic preform (10) intended for manufacturing a container, said process comprising at least steps consisting in succession in: (a) making at least one source (32) emit at least one ultraviolet (UV) emission; (b) reflecting said at least one emitted ultraviolet (UV) emission in order to direct it in the direction of the neck (18) of a preform (10); and (c) concentrating said at least one reflected ultraviolet (UV) emission by focusing it to obtain a beam that penetrates into the interior of the preform (10).