XIAOLIN HAO,TIMOTHY D. CUSHING,FELIX GONZALEZ LOPEZ DE TURISO,YOUNGSOOK SHIN
申请号：
MX2012006953
公开号：
MX2012006953A
申请日:
2010.12.17
申请国别(地区):
MX
年份:
2012
代理人:
摘要：
Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegrens syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia ( T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.Heteroarilos bicíclicos sustituidos y composiciones que los contienen, para el tratamiento de inflamación general, artritis, enfermedades reumáticas, osteoartritis, trastornos inflamatorios del intestino, trastornos inflamatorios de los ojos, trastornos inflamatorios o inestables de la vejiga, psoriasis, malestares de la piel con componentes inflamatorios, condiciones inflamatorias crónicas, incluyendo pero no restringidas a enfermedades autoinmunitarias tales como lupus sistémico eritematoso (SLE), miastenia gravis, artritis reumatoide, encefalomielitis diseminada aguda, purpura trombocitopénico idiopático, esclerosis múltiple, síndrome de Sjoegren, y anemia hemolítica autoinmunitaria, condiciones alérgicas que incluyen todas las formas de hipersensibilidad. La presente invención también facilita métodos para
