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DERIVE D'(AZA)INDOLIZINE ET SON UTILISATION PHARMACEUTIQUE
专利权人:
KISSEI PHARMACEUTICAL CO.; LTD.
发明人:
IIZUKA, MASATO,SHIMIZU, KAZUO
申请号:
CA2811773
公开号:
CA2811773A1
申请日:
2011.09.28
申请国别(地区):
CA
年份:
2012
代理人:
摘要:
Provided is a compound which is useful as a prophylactic or therapeutic agent for diseases or the like caused by abnormal serum urate level. An (aza)indolizine derivative represented by formula (I), said (aza)indolizine derivative having a xanthine oxidase inhibitory activity and being useful as a prophylactic or therapeutic agent for diseases caused by abnormal serum urate level, a prodrug thereof or a salt, etc. of the same. In formula (I), 0 to 2 of X1 to X4 represent a nitrogen atom and the remainder represent CR1; one of T1 and T2 represents cyano while the other represents a group represented by formula (A) [provided that when T1 is cyano, at least one of X1 to X4 represents a nitrogen atom]; R1s independently represent a hydrogen atom, a halogen atom, a hydroxyl group, C1-6 alkyl, C1-6 alkoxy, etc.; the ring U represents a benzene ring, etc.; m is an integer of 0 to 2; and R2s independently represent a fluorine atom, a hydroxyl group, etc.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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