THE DEPARTMENT OF HEALTH AND HUMAN SERVICES; AS REPRESENTED BY THE SECRETARY;THE GOVERNMENT OF THE UNITED STATES OF AMERICA
发明人:
NABEL, GARY,HUANG, YUE
申请号：
AT03751792
公开号：
AT544865T
申请日:
2003.07.11
申请国别(地区):
AT
年份:
2012
代理人:
摘要：
The present invention relates to assays for the identification of compounds that inhibit assembly of NP, VP35, and VP24, or inhibit the glycosylation of NP, required for nucleocapsid formation, for use as anti-viral agents. The invention also relates to assays for the identification of compounds that block glycosylation of proteins having a glycosylation domain that is substantially homologous to a glycosylation domain of NP required for polymerization. The invention further relates to pseudoparticles for presentation of antigens or antigenic epitopes for immunogenic or vaccination purposes.
