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COMPOSITIONS AND METHODS FOR TREATING VISUAL DISORDERS
专利权人:
发明人:
申请号:
EP11715842.8
公开号:
EP2558100A1
申请日:
2011.04.13
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
Disclosed are methods of treating disorders of the eye by administering to a patient in need of such treatment a compound represented by formula (I), Wherein R1 and R2 are independently hydrogen, alkyl, substituted alkyl, cycloalkyl, alkynyl, substituted alkynyl, cyano, alkoxy, carboxamido, substituted carboxamido, and if R1 and R2 are alkyl, R1 and R2 may be joined with a bond or --(CH2)m-- to produce a cycloalkyl, R3 and R4 are independently hydrogen, alkyl, hydroxyl, alkoxy, cyano, fluoro, and if R3 and R4 are alkyl, R3 and R4 may be joined with a bond or --(CH2)m-- to produce a cycloalkyl, Q may be absent, hydrogen, alkyl, cycloalkyl, cycloalkenyl, alkoxy, substituted alkoxy, substituted thio, cyano, thionitrile, sulfonamide, substituted sulfonamide, substituted sulfonyl, aromatic, substituted aromatic, heteroaromatic, substituted heteroaromatic, or bicycloheteroaromatic, R5 is hydrogen, alkyl, cycloalkyl, or when R6 is also alkyl, together with R6 may form a heterocydoalkyl ring, R6 may be hydrogen, alkyl, substituted alkyl, or --OR7, R7 is alkyl or, when R5 is alkyl, together with R5 forms a 5-, 6-, or 7-membered ring, L may be --Ο--, -S-, -N= or absent, Z may be carbon or nitrogen or absent, m is 1, 2 or 3, n is 0, 1 or 2, and when n is 0, Q may be directly bonded to Z, or a pharmaceutically acceptable addition salt of an acid or base thereof.Linvention concerne des procédés de traitement de troubles de lœil par ladministration, à un patient ayant besoin dun tel traitement, dun composé représenté par la formule (I), dans laquelle R1 et R2 représentent indépendamment hydrogène, alkyle, alkyle substitué, cycloalkyle, alcynyle, alcynyle substitué, cyano, alcoxy, carboxamido, carboxamido substitué, et si R1 et R2 représentent alkyle, R1 et R2 peuvent être réunis par une liaison ou ~(CH2)m~ pour donner un cycloalkyle, R3 et R4 représentent indépendamment hydrogène, alkyle, hydroxyle, alcoxy, cyano, fluoro, et si R3 et R4 représentent alkyle, R3 et R4 peuvent être
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