University of Pittsburgh—Of the Commonwealth System of Higher Education
发明人:
Soldano Ferrone,Xinhui Wang
申请号：
US14748123
公开号：
US09801928B2
申请日:
2015.06.23
申请国别(地区):
US
年份:
2017
代理人:
摘要：
It is disclosed herein that condroitin sulfate proteoglycan 4 (CSPG4), also known as high molecular weight melanoma associated antigen, is overexpressed on basal breast carcinoma cells (BBC), specifically triple negative basal breast carcinoma cells (TNBC). Methods for detecting basal breast cancer in a subject are disclosed. Methods are also disclosed for inhibiting the growth of a basal breast cancer cell. These methods include contacting the basal breast cancer cell with an effective amount of an antibody that specifically binds CSPG4. Additional treatment methods, and the use of antibody panels, are also described herein.
