A protective formulation for treatment of at least one side-effect associated with administration of at least one therapeutic agent includes a therapeutic amount of oxypurinol. A method for treatment of at least one side-effect associated with administration of at least one therapeutic agent to a patient includes applying or locally delivering a protective formulation including a therapeutic amount of oxypurinol to a site of protection of the patient. In some embodiments, the side-effect is hand-foot syndrome, the therapeutic agent includes a fluoropyrimidine, and the protective formulation is a topical formulation.
