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ROR GAMMA MODULATORS
专利权人:
ЭТХ ЦЮРИХ (CH)
发明人:
ВОЛЬФРУМ Кристиан (CH),КАРРЕЙРА Эрик (CH),МАЙССБУРГЕР Беттина (DE)
申请号:
RU2014115796/04
公开号:
RU2014115796A
申请日:
2012.09.18
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. The compound of formula I for use as a modulator of the receptor ROR-gamma, having the General formula I, or its pharmaceutically acceptable salts or stereoisomers: where R, R, R, independently of one another, mean H, halogen, -OR, -SR , -NRR, -COOR, -CONRR, where R and R, independently of one another, are H or (C1-6) alkyl, or R, R, together with the carbon atoms to which they are attached form an epoxy group; R, R , R, R, independently of one another, mean H, halogen, -OR, -SR, -NRR, -COOR, -CONRR, oxo, thio, where R and R, independently of one another, mean H or (C1-6 ) alkyl; R, R, R, independently of one another, means are H, (C1-10) alkyl, where one or more of the non-adjacent CH groups can be replaced by -O-, -S-, -CO-, -CO-O-, -O-CO-, -NR- , -CO-NR-, -NR-CO-, -C = C- or -C≡C-; where R is H or (C1-6) alkyl; L is a linking group, such as straight or branched chain C (1-12) alkyl, which is unsubstituted or substituted by at least one CN, halogen, OH, NRR, COOR, NO, and where one or more of the non-adjacent CH groups can be replaced by a group selected from the group consisting of -O-, -CO-, -CO-O-, -O-CO-, -NR-, -NR- CO-, -CO-NR-, -CH = CH-, -C≡C-; where R and R, independently of one another, are H or (C1-6) alkyl; X is H, —OR, —SR, —NRR, —COOR, —CONRR; where R and R, independently of one another, are H or (C1-6) alkyl, and R is —H, - (C1-6) alkyl, —NH— (CH) —COR or —NH— (CH) —SOR, where n, p are 1, 2 or 3 and R is —H or - (C1-6) alkyl; m is from 0 to 5.2. A compound according to claim 1, wherein R, R, R, independently of one another, are H, (C1-10) alkyl, more preferably methyl, ethyl, propyl, butyl, most preferably methyl. The compound according to claim 1 or 2, where R, R, independently of one another, are H, halogen, —OR, —COOR, where R is —H or - (C1-6) alkyl, or form, together with carbon atoms, with which1. Соединение формулы I для применения в качестве модулятора рецептора ROR-гамма, имеющее общую формулу I, или его фармацевтически приемлемые соли ил
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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