The invention refers to a synergistic combination comprising a Sigma ligand of general formula (I), and a Serotonin-Norepinephrine Reuptake Inhibitor (SNRI), a medicament comprising said active substance combination, and the use of said active substance combination for the manufacture of a medicament, particularly for the prophylaxis and/or treatment of pain.本發明涉及一種包含通式(I)的σ配體和血清素-去甲腎上腺素再攝取抑制劑(SNRI)的協同組合物,含有所述活性物質組合物的藥物,及所述活性物質組合物在製備藥物,特別是用於預防和/或治療疼痛的藥物中的用途。