A user-initiated fluid pathway connection includes: a connection hub (3310), a piercing member (330), a sterile sleeve (320), and a drug container (50) having a cap (52), a pierceable seal (56), a barrel (58), and a plunger seal (60), wherein the piercing member is initially retained within the sterile sleeve between the connection hub and the pierceable seal of the drug container. The connection hub includes an internal aperture (3310D) within the connection hub which functions as a flow restrictor and wherein a piercing member is connected to one end of the internal aperture and a fluid conduit is connected to another end of the internal aperture. A drug delivery pump (10) with integrated sterility maintenance features includes a housing (12), upon which an activation mechanism (14), an insertion mechanism (200), a fluid pathway connection as described above, a power and control system (400), and a drive mechanism (100) connected to a drug container are mounted.
