SCHWARZ MARGRIT,MEININGER DAVID PARK,SHAN BEI,ZHOU MINGYUE,BOONE THOMAS,WENYAN SHEN
申请号：
NZ61400108
公开号：
NZ614001A
申请日:
2008.07.25
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
A modified lecithin-cholesterol acyltransferase (LCAT) protein comprising at least one amino acid modification as compared to a mature human LCAT amino acid sequence, the mature sequence having at least 95% sequence identity to a sequence as set forth in SEQ ID NO: 1 or SEQ ID NO: 2 and an immunoglobulin G (IgG) constant (Fc) domain, wherein the modification to the LCAT protein sequence consists of a C31Y substitution and an F1 substitution selected from the group consisting of F1A, F1G, F1I, F1L, F1M, F1P, F1V, F1C, F1Y, F1T, F1Q, F1N, F1H and F1D.
