A preparation method of a hydrogel dressing is provided. A reaction mixture solution is formed, and the reaction mixture solution includes a polymerizable monomer, a crosslinking agent, and a polyol. A cooling process is performed on the reaction mixture solution to form a gel solution, wherein a temperature of the cooling process ranges from 0℃ to -20℃. The gel solution is coated on a matrix to form a gel coating. The gel coating is cross-linked to form a hydrogel layer on the matrix.一種水凝膠敷料的製備方法。形成反應混合溶液,反應混合溶液包括可聚合單體、交聯劑以及多元醇。對反應混合溶液進行冷卻製程,以形成膠體溶液,其中冷卻製程的溫度介於0℃至-20℃。將膠體溶液塗佈於基材上,以形成膠體塗層。使膠體塗層進行交聯反應,以於基材上形成水凝膠層。S100~S130‧‧‧步驟
