SCFV-FC DIMERS THAT BIND TRANSFORMING GROWTH FACTOR-BETA1 WITH HIGH AFFINITY, AVIDITY AND SPECIFICITY

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专利权人:

GENZYME CORPORATION

发明人:

Huawei Qiu,Clark Pan,Julie Bird

申请号：

US16669211

公开号：

US20200131258A1

申请日:

2019.10.30

申请国别(地区):

US

年份:

2020

代理人:

摘要：

An scFv-Fc dimer binds and neutralizes TGFβ1 selectively and with high affinity and avidity. The scFv region may comprise the same VH and VL domains or CDR regions as metelimumab. The unique combination of their smaller size, high selectivity, potency against TGFβ1, and long in vivo half-life makes the scFv-Fc dimers ideal candidates for therapeutic applications.

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中国工程科技知识中心

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