STCUBE, INC.;Board of Regents, The University of Texas System; INC.;STCUBE
发明人:
YOO, Stephen S.,CHUNG, Ezra M.,KIM, Yong-Soo,HUNG, Mien-Chie,LI, Chia-Wei,LIM, Seung-Oe
申请号：
EP16773987
公开号：
EP3277320A4
申请日:
2016.03.29
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
Antibodies that bind specifically to glycosylated PD-L1 relative to unglycosylated PD-L1 are provided. Antibodies that recognize specific epitopes of glycosylated PD-L1 protein and can block the binding of PD-L1 to PD-1 are provided. In some aspects, PD-L1 polypeptides comprising glycosylated amino acid residues at amino and carboxy terminal positions of the PD-L1 extracellular domain are also provided. Methods for making and using such antibodies and polypeptides (e.g., for the treatment of cancer) are also provided.
