: The present invention relates with pharmaceutical composition for the treatment of periodontal diseases e.g. periodontitis. The composition to be applied directly into the periodontal pocket where it is supposed to give extended drug release for longer time. In particular this invention relates to a process for making formulation for local delivery of active pharmaceutical substance for the treatment of periodontitis. Active may be selected from antibacterial, antibiotic, local anaesthetic or anti plaque and other as like with or without combination. Periodontitis (peri - around, odont = tooth, -itis = inflammation) refers to a number of inflammatory diseases affecting the periodontium- that is, the tissues that surround and support the teeth. Periodontitis involves progressive loss of the alveolar bone around the teeth, and if left untreated, can lead to the loosening and subsequent loss of teeth. Periodontitis is caused by bacteria that adhere to and grow on the tooths surfaces, along with an overly aggressive immune response against these bacteria. Most of the bacteria causing periodontitis includes anaerobic gram-negative bacteria in the subgingival area are Actinobaci-llusactinomycetemcomitans (Aa), Porphyromonas gingivalis, (Pg), Prevotella intermedia (Pi), and Tannerella forsythensis (Tf). These bacteria secrete colagenase that degrades periodontal ligament, connective tissue of the periodontal membrane. As a result periodontal membrane is separated and periodontal pocket is formed. Periodontitis can be diagnosed by inspecting the soft gum tissues around the teeth with a probe and radiographs by visual analysis, to determine the amount of bone loss around the teeth. The removal of the periodontal plaque is the primary treatment for periodontitis. The plaque can be removed with the use of chemotherapy or by root planning and scaling called apparatotherapy. There are lots of problem associated with root planning and scaling e. g. instruments cant reach the ar
