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CONTROLLED RELEASE SOLID DOSE FORMS
专利权人:
FMC CORPORATION
发明人:
SIEPMANN, JUERGEN,CUPPOK, YVONNE
申请号:
EP12792447
公开号:
EP2714015A4
申请日:
2012.05.23
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
The present invention is directed to a solid dose form comprising a film coating composition encapsulating a core, wherein: (i) the core comprises an active ingredient comprising at least one of a pharmaceutical, veterinary, or nutraceutical active ingredient (ii) the film coating composition comprises ethylcellulose and guar gum, wherein the guar gum has an apparent viscosity &gE151.0 cps at a shear rate of 50 s&minus1 in a 1% aqueous guar gum solution measured rotationally at 20° C. after 1 minute equilibration using a 6 cm acrylic cone (1°) on a cone-plate viscometer wherein the shear is ramped up linearly from 1 to 50 s&minus1 in 25 steps over 29 seconds (iii) the dose form provides controlled release of the active ingredient (iv) the guar gum is present in an amount greater than 5 wt % based on the weight of the guar gum and ethylcellulose and (v) the dose form is ethanol resistant.
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